Just saw this posted on Telegram by Dr. Zen Zelenko…
“Potential Marburg virus treatment
-not Corona variant
-Marburg is not spread through air
-spread through direct contact
-around 30% mortality rate
-stockpiled by Russia as bio weapon
-no known treatment
-Marburg virus is a ssRNA virus
-Marburg uses rdrp to replicate
https://pubmed.ncbi.nlm.nih.gov/1546452/
-Zinc inhibits ZAP protein
https://pubmed.ncbi.nlm.nih.gov/17182693/
ZINC/ZINC IONOPHORES may prevent and/or treat Marburg
Vladimir Zev Zelenko MD”
On the NIH paper we find…
“Inhibition of filovirus replication by the zinc finger antiviral protein
Abstract
The zinc finger antiviral protein (ZAP) was recently shown to inhibit Moloney murine leukemia virus and Sindbis virus replication. We tested whether ZAP also acts against Ebola virus (EBOV) and Marburg virus (MARV). Antiviral effects were observed after infection of cells expressing the N-terminal part of ZAP fused to the product of the zeocin resistance gene (NZAP-Zeo) as well as after infection of cells inducibly expressing full-length ZAP. EBOV was inhibited by up to 4 log units, whereas MARV was inhibited between 1 to 2 log units. The activity of ZAP was dependent on the integrity of the second and fourth zinc finger motif, as tested with cell lines expressing NZAP-Zeo mutants. Heterologous expression of EBOV- and MARV-specific sequences fused to a reporter gene suggest that ZAP specifically targets L gene sequences. The activity of NZAP-Zeo in this assay was also dependent on the integrity of the second and fourth zinc finger motif. Time-course experiments with infectious EBOV showed that ZAP reduces the level of L mRNA before the level of genomic or antigenomic RNA is affected. Transient expression of ZAP decreased the activity of an EBOV replicon system by up to 95%. This inhibitory effect could be partially compensated for by overexpression of L protein. In conclusion, the data demonstrate that ZAP exhibits antiviral activity against filoviruses, presumably by decreasing the level of viral mRNA.”
“Potential Marburg virus treatment
-not Corona variant
-Marburg is not spread through air
-spread through direct contact
-around 30% mortality rate
-stockpiled by Russia as bio weapon
-no known treatment
-Marburg virus is a ssRNA virus
-Marburg uses rdrp to replicate
https://pubmed.ncbi.nlm.nih.gov/1546452/
-Zinc inhibits ZAP protein
https://pubmed.ncbi.nlm.nih.gov/17182693/
ZINC/ZINC IONOPHORES may prevent and/or treat Marburg
Vladimir Zev Zelenko MD”
On the NIH paper we find…
“Inhibition of filovirus replication by the zinc finger antiviral protein
Abstract
The zinc finger antiviral protein (ZAP) was recently shown to inhibit Moloney murine leukemia virus and Sindbis virus replication. We tested whether ZAP also acts against Ebola virus (EBOV) and Marburg virus (MARV). Antiviral effects were observed after infection of cells expressing the N-terminal part of ZAP fused to the product of the zeocin resistance gene (NZAP-Zeo) as well as after infection of cells inducibly expressing full-length ZAP. EBOV was inhibited by up to 4 log units, whereas MARV was inhibited between 1 to 2 log units. The activity of ZAP was dependent on the integrity of the second and fourth zinc finger motif, as tested with cell lines expressing NZAP-Zeo mutants. Heterologous expression of EBOV- and MARV-specific sequences fused to a reporter gene suggest that ZAP specifically targets L gene sequences. The activity of NZAP-Zeo in this assay was also dependent on the integrity of the second and fourth zinc finger motif. Time-course experiments with infectious EBOV showed that ZAP reduces the level of L mRNA before the level of genomic or antigenomic RNA is affected. Transient expression of ZAP decreased the activity of an EBOV replicon system by up to 95%. This inhibitory effect could be partially compensated for by overexpression of L protein. In conclusion, the data demonstrate that ZAP exhibits antiviral activity against filoviruses, presumably by decreasing the level of viral mRNA.”
A couple other patrons were taking note too.
